SIRT1 and Insulin resistance: Body weight, insulin resistance index (HOMA-IR), and mRNA expression of perilipin 1 was measured in both adipose and skeletal muscle tissues, whereas perilipin 5, fat-specific protein 27 (FSP-27), adipose triglyceride lipase (ATGL), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1<i>α</i>), sirtuin 1 (SIRT1), and AMP-activated protein kinase (AMPK) were measured only in skeletal muscle after the subsequent 8-week intervention period.<h4>Results</h4>At baseline, no significant differences in body weight were observed among the groups (<i>p</i>  > 0.05).