Up-regulation of <i>circ_WHSC1</i> in breast tumor was linked with lymph node invasion (p-value = 0.005), HER2 negativity (p-value = 0.031) and positive family history (p-value = 0.012).<h4>Conclusion</h4>Cumulatively, <i>circ_WHSC1/miR-145-5p</i> can be suggested as a potential molecular axis contributing to the pathogenesis of breast cancer. The gene discussed is ERBB2; the disease is breast neoplasm.