Logistic regression analysis showed that advanced age (odds ratio (OR): 1.273, 95% confidence interval (CI): 1.099-1.473, <i>p</i> = 0.001), overweight (OR: 1.175, 95% CI: 1.039-1.328, <i>p</i> = 0.010), smoking (OR: 1.238, 95% CI: 1.049-1.462, <i>p</i> = 0.012), alcoholism (OR: 1.445, 95% CI: 1.040-2.007, <i>p</i> = 0.028), hypertension (OR: 1.229, 95% CI: 1.047-1.442, <i>p</i> = 0.012), dyslipidemia (OR: 3.027, 95% CI: 2.641-3.469, <i>p</i> < 0.001), <i>CYP2C19</i> IM/PM phenotype(IM + PM vs. EM phenotype, OR: 1.290, 95% CI: 1.140-1.459, <i>p</i> < 0.001) were associated with CAS in T2DM. This evidence concerns the gene CYP2C19 and Hypertension.