Significant risk factors for ARDS included pneumonia (OR = 2.88, 95% CI: 2.07-3.99), pancreatitis (OR = 2.45, 95% CI: 1.87-3.21), septic shock (OR = 1.78, 95% CI: 1.38-2.31), smoking (OR = 2.23, 95% CI: 1.33-3.75), elevated Sequential Organ Failure Assessment (SOFA) (OR per point = 1.15, 95% CI: 1.10-1.21) and APACHE II scores (OR per point = 1.12, 95% CI: 1.04-1.20), CRP (OR = 1.01), and serum creatinine (Scr) (OR = 1.07). The gene discussed is CRP; the disease is susceptibility to pneumonia measurement.