CXCR2 and Cowden disease: Based on the miRNA-hub gene regulatory network, hsa-miR-1-3p and hsa-miR-335-5p were recognized as potentially vital miRNAs.<h4>Conclusion</h4>Three hub genes (<i>CXCL1</i>, <i>CXCL2</i>, and <i>CXCR2</i>) and two miRNAs (hsa-miR-1-3p and hsa-miR-335-5p) are postulated to play a role in the initiation and progression of CD, thereby offering potential as biomarkers for this condition.