KFRE under-estimated the risk in the study cohort, however, with an observed-expected event probability ratio of 2.11, suggesting that recalibration is required.<h4>Conclusions</h4>The findings of the study indicate that predicting the risk of kidney failure with high accuracy in a general population of patients with chronic kidney disease is possible based on data that are routinely available, without requiring data for the urine albumin to creatinine ratio. The gene discussed is ALB; the disease is kidney failure.