<h4>Objective</h4>To explore the effects of oxytocin administration on social cognition and social engagement in patients with behavioral variant frontotemporal dementia.<h4>Methods</h4>In a within-subject, double-blind, placebo-controlled, randomized crossover trial, patients with behavioral variant frontotemporal dementia completed the primary outcome measures, facial emotion and intention recognition tasks. Here, OXT is linked to behavioral variant of frontotemporal dementia.