We identified <i>CTHRC1</i> (Collagen Triple Helix Repeat Containing 1) as a novel candidate associated with cognitive function and neurodegeneration.<h4>Methods</h4>Human proteomic analysis revealed <i>CTHRC1</i> as highly upregulated in AD patients (~5-fold increase, adj. This evidence concerns the gene CTHRC1 and Alzheimer disease.