<h4>Purpose</h4>To report an unusual presentation of bilateral myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) associated with optic neuritis occurring during the early post-operative cataract surgical period.<h4>Methods</h4>This was an observational case report.<h4>Results</h4>A 67-year-old Caucasian female presented with right eye visual acuity decrease occurring five days after bilateral cataract surgery. This evidence concerns the gene MOG and optic neuritis.