TNF and hemophilia: The association between TNF-α gene polymorphisms and inhibitor formation in hemophilia has been explored.<h4>Aim</h4>To systematically review and quantitatively synthesize available evidence on the association between TNF-α gene polymorphisms and the development of inhibitors in patients with hemophilia.<h4>Methods</h4>A comprehensive literature search was conducted in PubMed and SciELO from inception to 11 February 2025.