In addition to proteins known to be secreted, we identified several putatively intracellular, non-N-glycosylated proteins, such as β-glucocerebrosidase and paladin, linked to pancreatic cancer (PC) as well as proteins associated with extracellular vesicles (EVs) in PC, such as dCTP pyrophosphatase 1. This evidence concerns the gene PALD1 and pancreatic neoplasm.