In a dextran sulfate sodium-induced colitis mouse model, oral administration of EPICERTIN reduced neutrophil infiltration and increased CX3CR1<sup>+</sup>MHCII<sup>lo/-</sup> (M2-like) over CX3CR1<sup>+</sup>MHCII<sup>hi</sup> (M1-like) macrophages in the colon lamina propria. The gene discussed is CX3CR1; the disease is colitis.