In postmenopausal women, obesity was associated with a moderate higher risk of ER-positive BC (pOR 1.29; 95 % CI 1.18-1.41), while overweight was associated with an increased risk of ER-positive (pOR 1.14; 95 % CI 1.06-1.22) and HER2-positive BC (pOR 1.13; 95 % CI 1.05-1.22). The gene discussed is ERBB2; the disease is Obesity.