In the multivariate regression model adjusted for age and sex, individuals with comorbidity exhibited significantly elevated IgG responses, showing a 1.38-fold increase to GLURP-R0 (β = 0.32 [95% CI: 0.07-0.59], p = 0.027) and a 1.34-fold higher response to MSP1 (β = 0.29 [95% CI: 0.02-0.47], p = 0.048), relative to the malaria-only group.<h4>Conclusion</h4>These findings suggest that diabetes may enhance malaria parasite multiplication while also augmenting IgG antibody responses to malaria vaccine candidate antigens in individuals with comorbidity. The gene discussed is ATAD1; the disease is diabetes mellitus.