Importantly, <i>Pc</i>-infected iNOS<sup>-/-</sup>, TNFR<sup>ΔLyz2</sup> and <i>HIF-1</i> <i>α</i> <sup>ΔLyz2</sup> mice show impaired release of TNF and glycolysis in monocytes, along with increased parasitemia and disease tolerance. The gene discussed is TNF; the disease is parasitic infectious disease.