We previously found that amyloid filaments of TATA-binding protein-associated factor 15 (TAF15) characterise a subtype of frontotemporal lobar degeneration with FET protein-immunoreactive inclusions (FTLD-FET)<sup>3</sup>, termed atypical FTLD with ubiquitin-positive inclusions (aFTLD-U)<sup>4</sup>, which causes early-onset, rapidly progressive behavioural variant frontotemporal dementia (FTD). Here, TAF15 is linked to frontotemporal dementia.