PIK3CA and neoplasm: Persons who have a more pro-inflammatory lifestyle may have an increased recurrence risk (IRR 1.21, 95% CI 0.97-1.52), which was most pronounced for persons with MSS and <i>KRAS</i> or <i>PIK3CA</i> wildtype tumours (IRR 1.31, 95% CI 0.90-1.90 and IRR 1.30, 95% CI 0.98-1.71, respectively).<h4>Conclusion</h4>Our results suggest that associations between the LIS and recurrence might differ based on molecular tumour characteristics.