Here, we aimed to investigate the potential role of TRIM13 restriction in promoting the DC-mediated immune response during sepsis.<h4>Methods</h4>Splenic DCs were isolated from wild-type (WT) and DC-specific <i>Trim13</i> conditional knockout (<i>Trim13</i> cKO) mice post-cecum ligation and puncture (CLP). Here, TRIM13 is linked to Sepsis.