This study aims to assess and correlate the relationship between serum vitamin D levels, salivary antimicrobial peptides (AMPs), and their role in oral health.<h4>Materials and methods</h4>A total of 80 individuals aged 35-75 years were recruited, including 40 patients in the metabolic syndrome group, following the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria, and 40 in the non-metabolic group. The gene discussed is ADSL; the disease is metabolic syndrome.