CRP and cancer: Risk signatures confirmed age as the dominant risk factor (hazard ratio 1.15 per year, 95% confidence interval 1.13-1.18) and highlighted interaction effects: younger men with cancer history had higher PCa risk, while elevated CRP with high CCI amplified risk, demonstrating strong predictive accuracy (receiver operating characteristic area under the curve: 0.82; Harrell's C: 0.72).