While both groups showed increased asthma control test (ACT) scores, the non-ACO-A group displayed decreased fractional exhaled nitric oxide (FeNO) and eosinophil (EOS) (all <i>p</i> < 0.001) and increased serum total IgE, pre-BD FEV<sub>1</sub>%predicted, post-BD FEV<sub>1</sub>%predicted, and post-BD FEV<sub>1</sub>/FVC (all <i>p</i> < 0.001). The gene discussed is IGHE; the disease is asthma.