Additionally, RSV reduced adhesion molecule expression, including vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), P-selectin, and von Willebrand Factor (vWF), while promoting vasodilation and endothelial protection through increased nitric oxide (NO) production, SIRT1 activation, and ANGPT2 expression.<h4>Conclusion</h4><i>In vivo</i> and <i>in vitro</i> studies have revealed that RSV has promising effects on DVT and PE. The gene discussed is SIRT1; the disease is deep vein thrombosis.