TNF and thalassemia: Polyphenols also reduce inflammation and oxidative stress by reducing tumor necrosis factor-α, C-reactive protein and malondialdehyde, and increasing total antioxidant capacity.<h4>Conclusion</h4>The iron-chelating capacity of polyphenols and flavonoids which may have fewer side effects in patients with thalassemia, has garnered significant attention and holds a promise for therapeutic purposes.