Because intestinal MCs express the non-IgE-dependent activation receptor MRGPRX2, we investigated whether MRGPRX2 expression and MC phenotypes are altered in individuals with HαT in the context of inflammatory bowel disease (IBD).<h4>Methods</h4>We genotyped 854 biobanked IBD samples to identify individuals with HαT. This evidence concerns the gene TMPRSS11D and inflammatory bowel disease.