MRGPRX2 and inflammatory bowel disease: Both spatial transcriptomics and ddPCR demonstrated significantly increased <i>MRGPRX2</i> and <i>SIGLEC8</i> transcript levels in IBD samples from individuals with HαT compared with matched non-HαT IBD controls.<h4>Discussion</h4>These findings suggest that enhanced MRGPRX2 expression and mast cell activation may contribute to gastrointestinal symptoms in individuals with HαT, particularly in the setting of IBD.