Targeting <i>CCND1</i> and its OS-mediated regulatory pathways offers a promising therapeutic strategy for PTC.<i>CCND1</i>, oxidative stress, papillary thyroid carcinoma, single-cell RNA sequencing, <i>SOX4</i>, <i>TFF3</i>. The gene discussed is CCND1; the disease is thyroid gland papillary carcinoma.