FLG and Alzheimer disease: Furthermore, it enhanced the expression of skin barrier proteins such as filaggrin, occludin, and ZO-1, and downregulated the expression of phosphorylated PI3K, AKT, and NF-κB (p-PI3K, p-AKT, and p-NF-κB) proteins.<h4>Conclusion</h4>The BHG exhibits favorable biocompatibility and potent antibacterial activity, and is capable of restoring the skin barrier and ameliorating dermatological symptoms in AD mice.