Furthermore, it enhanced the expression of skin barrier proteins such as filaggrin, occludin, and ZO-1, and downregulated the expression of phosphorylated PI3K, AKT, and NF-κB (p-PI3K, p-AKT, and p-NF-κB) proteins.<h4>Conclusion</h4>The BHG exhibits favorable biocompatibility and potent antibacterial activity, and is capable of restoring the skin barrier and ameliorating dermatological symptoms in AD mice. Here, OCLN is linked to Alzheimer disease.