Finally, we explored the impact of KIF20A on the biological behaviors of Kidney Renal Clear Cell Carcinoma (KIRC) cells through <i>in vitro</i> and <i>in vivo</i> experiments.<h4>Results</h4>KIF20A is localized in the nucleus and participates in the cell cycle process, serving as a core gene for tumor cell growth. This evidence concerns the gene KIF20A and neoplasm.