Sex-stratified multivariate analysis revealed that lower IFN-γ was associated with TB history in males (AOR 0.99, p=0.048), while lower IL-5 was associated with TB history in females (AOR 0.99, p=0.042).<h4>Conclusion</h4>A history of TB is associated with hypertension in PWH, particularly among females, and is linked to sex-specific differences in residual inflammatory pathways. The gene discussed is IL5; the disease is tuberculosis.