A 28-year-old patient with a known history of hypothyroidism, type 2 diabetes mellitus (T2DM) on SGLT2 inhibitors, polycystic ovarian syndrome (PCOS) and mixed anxiety-depressive disorder presented to the accident and emergency department with palpitations, chest discomfort and focal seizures reported by her partner and family. This evidence concerns the gene SLC5A2 and hypothyroidism.