IL-6 was significantly higher (<i>p</i> < 0.05) in the lungs and perirenal adipose tissue, and showed a higher trend in the kidney (0.05 ≤ <i>p</i> ≤ 0.1); IL-1β had a higher trend in the lungs; TNFα was significantly lower in the kidney but showed a higher trend in the lungs; while MCP-1 was significantly lower in the lungs, plasma, and inguinal adipose tissue of mice with obesity compared to non-obese mice. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.