Whole-exome sequencing, RNA sequencing, and methylation analyses of peripheral blood and/or tumor specimens were performed.<h4>Results</h4>Nineteen (79%) of 24 participants had NS, 17/19 (89%) of which had a germline <i>PTPN11</i> variant; Nineteen of 24 participants (79%) were male. This evidence concerns the gene PTPN11 and neoplasm.