FUT4 and hand eczema: <h4>Background</h4>Distinguishing hand eczema from palmar psoriasis is a common diagnostic challenge due to overlapping clinical and histopathological features.<h4>Objective</h4>This study aimed to validate morphological and immunohistochemical criteria for differentiating these two conditions using the digital pathology tools QuPath and ImageJ.<h4>Methods</h4>One hundred forty-two histological samples with confirmed clinical diagnoses were stained with hematoxylin and eosin and subjected to immunohistochemical staining for CD3, CD15, CD20, CD123, S100, and PHH3.