Wilms tumor 1-associating protein (WTAP) is a key component of the N6-methyladenosine (m6A) methyltransferase complex, and has an unclear role in periodontitis pathogenesis, particularly concerning its regulatory functions in periodontal ligament stem cells (PDLSCs).<h4>Methods</h4>The target gene was identified through the GES260558 dataset and Genecards database. Here, WTAP is linked to periodontitis.