<h4>Objectives</h4>The purpose of this study is to investigate the impact of Glucagon-like peptide-1 receptor agonists (GLP-1RAs) use on 90-day postoperative outcomes and overall survival following partial nephrectomy (PN) for renal cell carcinoma (RCC), where type 2 diabetes mellitus (T2DM) is a common comorbidity.<h4>Materials and methods</h4>The TriNetX database was used to retrospectively identify T2DM patients who underwent PN. This evidence concerns the gene GLP1R and renal cell carcinoma.