Targeted next-generation sequencing identified co-occurring KRAS and TP53 mutations along with a truncating AXIN2 variant, suggesting concurrent activation of the RAS/MAPK and Wnt/β-catenin pathways.<h4>Conclusion</h4>Pulmonary colloid adenocarcinoma can clinically and radiologically mimic a lung abscess. This evidence concerns the gene KRAS and lung abscess.