This research investigated the impact of tBHQ on the amelioration of PTSD-induced depression- and anxiety-like behaviors with respect to amygdala and hippocampal MAO-A, MAO-B, IL-6, IL-10, and glucocorticoid receptor in rats.<h4>Materials and methods</h4>PTSD was triggered through the use of Single Prolonged Stress (SPS). Here, NR3C1 is linked to major depressive disorder.