Renal sarcoidosis often presents diagnostic challenges, PTH-independent hypercalcemia may be a clinical feature.<h4>Case report</h4>A 48-year-old Asian female presented with persistent hypercalcemia (2.81 mmol/L), suppressed Parathyroid hormone PTH(1.24 pg/mL), and renal dysfunction (serum creatinine 2.02 mg/dL). The gene discussed is PTH; the disease is Hypercalcemia.