IRAK4 and nervous system disorder: They attenuate inflammation-induced disorders such as cardiovascular and neurological disorders via down-regulating pro-inflammatory cytokines (IL-6, CRP, COX-2, LPO, TGF-β1, NF-κB, and TNF-α), and pathways (IRAK4, MAPK, JAK/STAT3, TLR4, and ERK).