The free radical scavenging potential of <i>Salvia coccinea</i> and apigenin is responsible for reduced oxidative stress and tumor cell metastasis modulated through PARP-cleavage, caspase-3, ERK, CDK-1, JAK2/STAT3, Bax/Bcl-2, AMPK, and Wnt/β-catenin pathways. Here, STAT3 is linked to neoplasm.