PLOD1 and Insulin resistance: Significant improvements were also observed in Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) (SMD = -0.81, 95% CI: -1.02 to -0.60, p < 0.001; very low certainty), body mass index (BMI) (SMD = -0.95, 95% CI: -1.09 to -0.81, p < 0.001; low certainty), total testosterone (TT) (SMD = -0.90, 95% CI: -1.10 to -0.69, p < 0.001; very low certainty), and the luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio (SMD = -0.88, 95% CI: -1.05 to -0.70, p < 0.001; low certainty).