Interestingly, <i>SOD1</i> and <i>NQO1</i> genes, involved in oxidative stress response, were significantly upregulated by ER in HCT116 cells.<h4>Conclusion</h4>Our findings highlight <i>ASNS, CHAC1, PCK2, DDIT4, and ATF3/4</i> as potential biomarkers for ferroptosis in CRC. This evidence concerns the gene DDIT4 and colorectal carcinoma.