NTN1 and diabetic kidney disease: The total effective rate in the observation group (100.00%) was significantly higher than that in the traditional Chinese medicine group (86.00%) and western medicine group (78.00%), and the difference was statistically significant.<h4>Conclusion</h4>Combination of modified Shenqi Pills with conventional western medicine can achieve a more satisfactory effect in diabetic nephropathy, by reducing Netrin-1, promoting renal function recovery, eliminating edema and decreasing blood pressure.