<h4>Background</h4>Increased use of oral contraceptives and implants has necessitated the need to examine biochemical changes associated with their use.<h4>Objectives</h4>This study assessed insulin resistance, lipid profile, superoxide dismutase, glutathione peroxidase, adiponectin and leptin levels in women using oral and implant contraceptives in Calabar.<h4>Methods</h4>Ninety women aged 18-45years were recruited for this case-control study. The gene discussed is ADIPOQ; the disease is Insulin resistance.