MGI was performed in 66 children; pathogenic variants were detected in 53.1%, most frequently in the DICER1, PTEN, and APC genes.<h4>Conclusion</h4>Differentiated thyroid carcinoma in children is characterized by a number of clinical and molecular genetic features, which determines the need for a specialized multidisciplinary approach to their management. Here, APC is linked to thyroid gland carcinoma.