HIF1A and neoplasm: This approach enabled the identification of key modulatory factors, underlying mechanisms, and evolving research trajectories related to TCM-mediated regulation of tumor microcirculation.<h4>Results</h4>Our findings reveal that TCM formulations and their active constituents-such as Tao Hong Si Wu Decoction, ginsenoside Rg3, and tanshinone IIA-modulate angiogenesis and enhance immune cell infiltration through signaling pathways including VEGF, PI3K/AKT, and HIF-1α.