Furthermore, spatial transcriptomics data revealed that CEACAM6 expression was significant positively associated with malignant cells, while there was a negative correlation was observed with between CEACAM6 expression and plasma cells.<h4>Conclusion</h4>CEACAM6 exhibits high diagnostic accuracy and tumor-specific overexpression in pan-gastrointestinal cancers. This evidence concerns the gene CEACAM6 and neoplasm.