IL17A and rheumatoid arthritis: Single-cell analysis localised core gene expression to NK cells, monocytes and T/B cells, and highlighted inflammatory ligand-receptor interactions.<h4>Conclusions</h4>Integrative, ML-assisted transcriptomics reveals convergent RA-DM programmes centred on IL-17, TLR and chemokine pathways with remodelling of the immune microenvironment.