NPTXR and Sepsis: Cardiac function, vascular hemodynamics, endothelial integrity, and biomarkers of inflammation were analyzed in wild-type, endothelium-restricted (ecCNP<sup>-/-</sup>), or cardiomyocyte-restricted (cmCNP<sup>-/-</sup>) CNP knockout animals, or global NPR (natriuretic peptide receptor)-C<sup>-/-</sup> deficient mice, in etiologically distinct models of sepsis.