IGFL1 and colorectal carcinoma: This study therefore aims to elucidate the involvement of IGFL1 in CRC through an integrated approach combining bioinformatics analysis and experimental validation.<h4>Methods</h4>The expression of IGFL1 in CRC and its association with clinicopathological features, diagnostic relevance, and patient prognosis were evaluated using data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases.