Conclusively, our exploratory observed that <i>MAFG</i>, <i>AKAP1</i>, <i>TLR5</i>, <i>CHUK, EMC10,</i> and <i>PLRG1</i> variants had higher impacts and might be related to premature CHD development. The gene discussed is PLRG1; the disease is coronary artery disorder.