Nevertheless, results from randomized-controlled clinical trials (RCTs) remain conflicting.<h4>Objectives</h4>To assess the safety and efficacy of GLP-1 RAs in PD.<h4>Design</h4>Systematic review and meta-analysis of randomized placebo-controlled clinical trials.<h4>Data sources and methods</h4>A systematic search of MEDLINE and Scopus databases was conducted on October 7, 2025, for randomized placebo-controlled clinical trials investigating GLP-1 RAs in adults with PD. This evidence concerns the gene GLP1R and Parkinson disease.